Borage seed oil has one of the highest amounts of γ-linolenic acid (GLA) of seed oils — higher than blackcurrant seed oil or evening primrose oil, to which it is considered similar. GLA comprises around 24% of the oil typically. GLA is converted to dihomo-gamma-linolenic acid, a precursor to a variety of the series prostaglandins and the series leukotrienes. It is thought to provide therapeutic benefit in rheumatologic illness by inhibiting leukotriene synthesis. Borage seed oil may therefore have anti-inflammatory and anti-thrombotic effects and it has been studied for its potential to treat anti-inflammatory disorders, arthritis, atopic eczema, and respiratory inflammation. However, several clinical studies have shown it to be ineffective at treating atopic eczema.